Posts tagged with "Cognition"

Biogen’s Alzheimer’s treatment could be ‘the biggest drug ever’

October 23, 2019

Shares of Biogen soared 30% on Tuesday, October 22, CNBC reported, after the drugmaker announced it was seeking regulatory approval for the Alzheimer’s drug, Aducanumab, which it had announced it was at least temporarily giving up on earlier this year.

“It would be the biggest drug ever,” said CNBC’s Jim Cramer on “Squawk on the Street.”

The announcement  from Cambridge, Massachusetts-based Biogen and Tokyo-based Eisai—a leading global research and development-based pharmaceutical company—came after a consultation with the U.S. Food and Drug Administration (FDA) on plans to pursue a regulatory approval for the drug after a Phase 3 EMERGE Study met its primary endpoint—showing a significant reduction in clinical decline.

According to the joint research teams, ‘Patients who received Aducanumab experienced significant benefits on measures of cognition and function such as memory, orientation, and language. Patients also experienced benefits on activities of daily living—including conducting personal finances; performing household chores, such as cleaning, shopping, and doing laundry; and independently traveling out of the home.

They noted, “If approved, Aducanumab would become the first therapy to reduce the clinical decline of Alzheimer’s disease and would also be the first therapy to demonstrate that removing amyloid beta resulted in better clinical outcomes.”

Indeed, Biogen erased its entire 25% year-to-date decline after the announcement became public. The company plans to file for approval with the FDA in early 2020.

“The whole concept of senior living will change,” commented CNBC’s Cramer. “You know whose going to take this drug?” asked Cramer. “Everyone.”

Research contact: @CNBC

Study: Boogie down to get energy and cognition up

January 8, 2019

Older women who still enjoy dancing—whether it’s a waltz or the jitterbug—are likely to sustain better balance, muscle strength, and concentration than others in the same age group. In turn, these capabilities enable them to nimbly perform the activities of daily living (ADL).

A new study of “Exercise type and activities of living disability in older women,” conducted at the Tokyo Metropolitan Institute of Gerontology—and published in the Scandinavian Journal of Medicine and Science in Sports examined the potential effects of 16 different exercise types for reducing disability for activities of daily living in older women.

The study enrolled 1,003 community-dwelling older Japanese women without ADL disability, according to a report by Medical Life Sciences News . In the baseline survey, all participants were asked whether or not they participated in any of 16 exercise types. ADL disability during eight years of follow-up was defined as needing help in performing at least one ADL task (walking, eating, bathing, dressing, or toileting).

ADL disability was noted in 130 participants (13%) during follow-up. After adjusting for confounders, participation in dancing, compared with non-participation, was associated with a 73% lower likelihood for developing ADL disability. There were no significant associations between other exercise types and ADL disability.

“Although it is unclear why dancing alone reduced the risk of ADL disability, dancing requires not only balance, strength, and endurance ability, but also cognitive ability: adaptability and concentration to move according to the music and partner, artistry for graceful and fluid motion, and memory for choreography,” said lead author Dr. Yosuke Osuka, of the Tokyo Metropolitan Institute of Gerontology.” We think that these various elements may contribute to the superiority of dancing in maintaining a higher ADL capacity.”

Research contact: @tochu_koho